ApoE Gene Test


Our ApoE Gene Mutation Test Kit looks for the presence of the APOE4 variant, which is associated with increased risk of late-onset Alzheimer’s disease.


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What is ApoE, Apo-E, Apolipoprotein E?

The APOE gene makes a lipoprotein that is responsible for packaging cholesterol and other fats.  There are 3 alleles of the ApoE gene (E2, E3, E4) with E3 being most common in the US population. The other alleles or versions are associated with a number of health conditions related to ageing and cardiovascular disease

Conditions Associated with ApoE

  • Alzheimer Disease – APOE specifically carrying the E4 allele increases the risk for developing late-onset Alzheimer disease in people over 65. The risk is dependent on the number of copies of E4. An individual with 1 copy has a lifetime risk as high as 20% while having 2 copies of E4 can increase risk up to 50% However, the E2 variant can be protective.
  • Macular Degeneration – is a eye disease that results in vision loss usually in older adults.
  • Dementia with Lewy Bodies – The E4 variant can increase the risk of developing this type of dementia.

Sample Type

  • At-Home Test kit with a buccal swab collected with Zymo SafeCollect Swab

Why should I get tested?

  • If you have a strong family history of Alzheimer Disease or Dementia in the family
  • If you are developing signs of Dementia, Memory Loss, Alzheimer Disease or Macular Degeneration at an earlier than expected age
  • If you are starting to get forgetful, have confusion, or losing time
  • If there is age related impact on judgement
  • If there is any sign of progressive dementia

Turnaround time

  • Note: Result turnaround times are only an estimate and may be subject to change.
  • Test turnaround time for an electrolyte panel is typically 1-2 business days.

Patient Preparation

  • No special preparation is needed


  • These tests are meant for individual consumption. If you wish to order multiple test kits for multiple people, you will need to register as a provider.
  • How do I register as a provider?
Weight 1 lbs
Dimensions 10 × 6 × 1.25 in

Self-Test Collection Instructions

Please download the PDF below for sample collection instructions.

Buccal Swab PDF

Schedule Appointment


Locally in Central Florida:

Go to Patient Portal Page   1. Create Account. 2. Go to New Order and Schedule

Applied InGENuity Diagnostics Laboratory. Located at 7040 Lake Ellenor Dr, Orlando, FL 32809
Applied InGENuity Diagnostics Laboratory. Located at 7040 Lake Ellenor Dr, Orlando, FL 32809



  1. Please wait 24 hours for us to place your order
  2. Go to any Quest Patient Service Center




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