What is a Comprehensive Metabolic Panel (CMP)?

Doctor with a list of tests included with complete metabolic panel

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The main Purpose of this test is to see if there is a mutation of the MTHFR gene. Everyone has two of these genes but mutations can lead to health problems.

What Mutations does the MTHFR Test Look for?


The test looks specifically for two of the these mutations or variants: C677T and A1298C.

Can MTHFR Mutations be Harmful?


Research attributes these mutations to some unfavorable health issues. The main purpose of the MTHFR gene is to break down a substance called Homocysteine. This amino acid is used to help your body make proteins. If the MTHFR gene functions properly it disposes most of the leftover Homocysteine. However, mutations of the MTHFR gene can leave extra Homocysteine in the blood stream. Additionally, extra Homocysteine left in the blood stream can link to health problems such as, Homocystinuria, heart disease, stroke, high blood pressure, and blood clots.

Additional MTHFR Mutations Risks for Women


Unfortunately, women with MTHFR mutations have a greater chance of having a baby with one of the following birth defects: Spina bifida or Anencephaly. These can be reduced by taking folic acid or B vitamins.

We recommend pregnant women take folic acid supplements because it greatly reduces birth defects.

How do I know when to get Tested?


We recommend you get a test if any of the following are true for you: If you have a blood test that shows higher levels of Homocysteine, If you have a relative that has been diagnosed with an MTHFR mutation, or if you or close family members have a history of premature heart disease or blood vessel disorders.

If you need to test for MTHFR mutations, we offer the MTHFR Test Kit in the Test Kits section of our inventory. Click below to view our test kit


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  • U.S. National Library of Medicine. Comprehensive Metabolic Panel (CMP). (https://medlineplus.gov/lab-tests/comprehensive-metabolic-panel-cmp/) Accessed 11/9/2021.
  • Lab Tests Online. Comprehensive Metabolic Panel (CMP). (https://labtestsonline.org/tests/comprehensive-metabolic-panel-cmp) Accessed 11/9/2021.

Jack Towers

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